Evolution of Amino Acid Propensities under Stability-Mediated Epistasis

Site-specific amino acid preferences are influenced by the genetic background of the protein. The preferences for resident amino acids are expected to, on average, increase over time because of replacements at other sites—a nonadaptive phenomenon referred to as the “evolutionary Stokes shift.” Alter...

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Detalles Bibliográficos
Autores principales: Youssef, Noor, Susko, Edward, Roger, Andrew J, Bielawski, Joseph P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896634/
https://www.ncbi.nlm.nih.gov/pubmed/35134997
http://dx.doi.org/10.1093/molbev/msac030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896634/
https://www.ncbi.nlm.nih.gov/pubmed/35134997
http://dx.doi.org/10.1093/molbev/msac030

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