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Evolution of Amino Acid Propensities under Stability-Mediated Epistasis
Site-specific amino acid preferences are influenced by the genetic background of the protein. The preferences for resident amino acids are expected to, on average, increase over time because of replacements at other sites—a nonadaptive phenomenon referred to as the “evolutionary Stokes shift.” Alter...
Autores principales: | Youssef, Noor, Susko, Edward, Roger, Andrew J, Bielawski, Joseph P |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896634/ https://www.ncbi.nlm.nih.gov/pubmed/35134997 http://dx.doi.org/10.1093/molbev/msac030 |
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