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Lrh1 can help reprogram sexual cell fate and is required for Sertoli cell development and spermatogenesis in the mouse testis
The mammalian nuclear hormone receptors LRH1 (NR5A2) and SF1 (NR5A1) are close paralogs that can bind the same DNA motif and play crucial roles in gonadal development and function. Lrh1 is essential for follicle development in the ovary and has been proposed to regulate steroidogenesis in the testis...
Autores principales: | Agrimson, Kellie S., Minkina, Anna, Sadowski, Danielle, Wheeler, Andrew, Murphy, Mark W., Gearhart, Micah D., Bardwell, Vivian J., Zarkower, David |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896720/ https://www.ncbi.nlm.nih.gov/pubmed/35192609 http://dx.doi.org/10.1371/journal.pgen.1010088 |
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