A targeted covalent inhibitor of p97 with proteome-wide selectivity

A resurging interest in targeted covalent inhibitors (TCIs) focus on compounds capable of irreversibly reacting with nucleophilic amino acids in a druggable target. p97 is an emerging protein target for cancer therapy, viral infections and neurodegenerative diseases. Extensive efforts were devoted t...

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Detalles Bibliográficos
Autores principales: Ye, Zi, Wang, Ke, Chen, Lianguo, Jin, Xiaofeng, Chen, Hao, Tang, Guanghui, Yao, Shao Q., Feng, Zhiqiang, Zhang, Chong-Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897041/
https://www.ncbi.nlm.nih.gov/pubmed/35256959
http://dx.doi.org/10.1016/j.apsb.2021.09.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897041/
https://www.ncbi.nlm.nih.gov/pubmed/35256959
http://dx.doi.org/10.1016/j.apsb.2021.09.003

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