Canonical TGFβ signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMT

Local invasion is the initial step towards metastasis, the main cause of cancer mortality. In human colorectal cancer (CRC), malignant cells predominantly invade as cohesive collectives and may undergo partial epithelial-mesenchymal transition (pEMT) at the invasive front. How this particular mode o...

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Detalles Bibliográficos
Autores principales: Flum, Marion, Dicks, Severin, Teng, Yu-Hsiang, Schrempp, Monika, Nyström, Alexander, Boerries, Melanie, Hecht, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897192/
https://www.ncbi.nlm.nih.gov/pubmed/35075245
http://dx.doi.org/10.1038/s41388-022-02190-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897192/
https://www.ncbi.nlm.nih.gov/pubmed/35075245
http://dx.doi.org/10.1038/s41388-022-02190-4

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