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Targeting glutamine utilization to block metabolic adaptation of tumor cells under the stress of carboxyamidotriazole-induced nutrients unavailability

Tumor cells have unique metabolic programming that is biologically distinct from that of corresponding normal cells. Resetting tumor metabolic programming is a promising strategy to ameliorate drug resistance and improve the tumor microenvironment. Here, we show that carboxyamidotriazole (CAI), an a...

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Detalles Bibliográficos
Autores principales: Shi, Jing, Ju, Rui, Gao, Hongting, Huang, Yuqing, Guo, Lei, Zhang, Dechang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897199/
https://www.ncbi.nlm.nih.gov/pubmed/35256945
http://dx.doi.org/10.1016/j.apsb.2021.07.008