A novel inhibitor of N(6)-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities

N(6)-methyladenosine (m(6)A) modification is critical for mRNA splicing, nuclear export, stability and translation. Fat mass and obesity-associated protein (FTO), the first identified m(6)A demethylase, is critical for cancer progression. Herein, we developed small-molecule inhibitors of FTO by virt...

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Detalles Bibliográficos
Autores principales: Xie, Guoyou, Wu, Xu-Nian, Ling, Yuyi, Rui, Yalan, Wu, Deyan, Zhou, Jiawang, Li, Jiexin, Lin, Shuibin, Peng, Qin, Li, Zigang, Wang, Hongsheng, Luo, Hai-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897214/
https://www.ncbi.nlm.nih.gov/pubmed/35256950
http://dx.doi.org/10.1016/j.apsb.2021.08.028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897214/
https://www.ncbi.nlm.nih.gov/pubmed/35256950
http://dx.doi.org/10.1016/j.apsb.2021.08.028

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