Cargando…
Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies
Protein misfolding is a general hallmark of protein deposition diseases, such as Alzheimer’s disease or Parkinson’s disease, in which different types of aggregated species (oligomers, protofibrils and fibrils) are generated by the cells. Despite widespread interest, the relationship between oligomer...
Autores principales: | Cascella, Roberta, Bigi, Alessandra, Cremades, Nunilo, Cecchi, Cristina |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897347/ https://www.ncbi.nlm.nih.gov/pubmed/35244787 http://dx.doi.org/10.1007/s00018-022-04166-9 |
Ejemplares similares
-
α-Synuclein oligomers and fibrils: partners in crime in synucleinopathies
por: Bigi, Alessandra, et al.
Publicado: (2023) -
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells
por: Cascella, Roberta, et al.
Publicado: (2021) -
Exploring the Release of Toxic Oligomers from α-Synuclein Fibrils with Antibodies and STED Microscopy
por: Bigi, Alessandra, et al.
Publicado: (2021) -
Characterization
of Pairs of Toxic and Nontoxic Misfolded
Protein Oligomers Elucidates the Structural Determinants of Oligomer
Toxicity in Protein Misfolding Diseases
por: Limbocker, Ryan, et al.
Publicado: (2023) -
Toxic species in amyloid disorders: Oligomers or mature fibrils
por: Verma, Meenakshi, et al.
Publicado: (2015)