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Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP

Mechanical forces regulate multiple essential pathways in the cell. The nuclear translocation of mechanoresponsive transcriptional regulators is an essential step for mechanotransduction. However, how mechanical forces regulate the nuclear import process is not understood. Here, we identify a highly...

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Detalles Bibliográficos
Autores principales: García-García, María, Sánchez-Perales, Sara, Jarabo, Patricia, Calvo, Enrique, Huyton, Trevor, Fu, Liran, Ng, Sheung Chun, Sotodosos-Alonso, Laura, Vázquez, Jesús, Casas-Tintó, Sergio, Görlich, Dirk, Echarri, Asier, Del Pozo, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897400/
https://www.ncbi.nlm.nih.gov/pubmed/35246520
http://dx.doi.org/10.1038/s41467-022-28693-y