SIRT6 mediates MRTF-A deacetylation in vascular endothelial cells to antagonize oxLDL-induced ICAM-1 transcription

Oxidized low-density lipoprotein (oxLDL), a known risk factor for atherosclerosis, activates the transcription of adhesion molecules (ICAM-1) in endothelial cells. We previously showed that myocardin-related transcription factor A (MRTF-A) mediates oxLDL-induced ICAM-1 transcription. Here we confirm...

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Detalles Bibliográficos
Autores principales: Huang, Shan, Shao, Tinghui, Liu, Hong, Wang, Qianyun, Li, Tianfa, Zhao, Qianwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897425/
https://www.ncbi.nlm.nih.gov/pubmed/35246513
http://dx.doi.org/10.1038/s41420-022-00903-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897425/
https://www.ncbi.nlm.nih.gov/pubmed/35246513
http://dx.doi.org/10.1038/s41420-022-00903-y

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