Ubiquitin and a charged loop regulate the ubiquitin E3 ligase activity of Ark2C

A large family of E3 ligases that contain both substrate recruitment and RING domains confer specificity within the ubiquitylation cascade. Regulation of RING E3s depends on modulating their ability to stabilise the RING bound E2~ubiquitin conjugate in the activated (or closed) conformation. Here we...

Descripción completa

Detalles Bibliográficos
Autores principales: Paluda, Andrej, Middleton, Adam J., Rossig, Claudia, Mace, Peter D., Day, Catherine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897509/
https://www.ncbi.nlm.nih.gov/pubmed/35246518
http://dx.doi.org/10.1038/s41467-022-28782-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897509/
https://www.ncbi.nlm.nih.gov/pubmed/35246518
http://dx.doi.org/10.1038/s41467-022-28782-y

Ejemplares similares