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Ubiquitin and a charged loop regulate the ubiquitin E3 ligase activity of Ark2C
A large family of E3 ligases that contain both substrate recruitment and RING domains confer specificity within the ubiquitylation cascade. Regulation of RING E3s depends on modulating their ability to stabilise the RING bound E2~ubiquitin conjugate in the activated (or closed) conformation. Here we...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897509/ https://www.ncbi.nlm.nih.gov/pubmed/35246518 http://dx.doi.org/10.1038/s41467-022-28782-y |