Target occupancy study and whole-body dosimetry with a MAGL PET ligand [(11)C]PF-06809247 in non-human primates

BACKGROUND: Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [(11)C]PF-06809247 into a clinically usable MAGL positron emission tomography (PE...

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Detalles Bibliográficos
Autores principales: Arakawa, Ryosuke, Takano, Akihiro, Nag, Sangram, Jia, Zhisheng, Amini, Nahid, Maresca, Kevin P., Zhang, Lei, Keliher, Edmund J., Butler, Christopher R., Piro, Justin R., Samad, Tarek A., Smith, Deborah, Nason, Deane, O’Neil, Steve, Trapa, Patrick, Fonseca, Kari R., Litchfield, John, McCarthy, Timothy, Carson, Richard E., Halldin, Christer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897535/
https://www.ncbi.nlm.nih.gov/pubmed/35244788
http://dx.doi.org/10.1186/s13550-022-00882-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897535/
https://www.ncbi.nlm.nih.gov/pubmed/35244788
http://dx.doi.org/10.1186/s13550-022-00882-2

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