Lazertinib improves the efficacy of chemotherapeutic drugs in ABCB1 or ABCG2 overexpression cancer cells in vitro, in vivo, and ex vivo

Multidrug resistance (MDR) is the major cause of chemotherapy failure, which is usually caused by the overexpression of ATP-binding cassette (ABC) transporters such as ABCB1 and ABCG2. To date, no MDR modulator has been clinically approved. Here, we found that lazertinib (YH25448; a novel third-gene...

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Detalles Bibliográficos
Autores principales: Fan, Yingfang, Tao, Tian, Guo, Zhixing, Wah To, Kenneth Kin, Chen, Da, Wu, Shaocong, Yang, Chuan, Li, Jinsui, Luo, Min, Wang, Fang, Fu, Liwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897717/
https://www.ncbi.nlm.nih.gov/pubmed/35284628
http://dx.doi.org/10.1016/j.omto.2022.02.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897717/
https://www.ncbi.nlm.nih.gov/pubmed/35284628
http://dx.doi.org/10.1016/j.omto.2022.02.006

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