Catalyst-free synthesis of tetrahydrodipyrazolopyridines via an one-pot tandem and green pseudo-six-component reaction in water

BACKGROUND: A new, green and environmentally friendly protocol has been developed for the synthesis of tetrahydrodipyrazolopyridine derivatives. The structures of these products were determined in terms of melting point, FTIR, NMR and Mass spectroscopy. RESULTS: The tetrahydrodipyrazolopyridine deri...

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Detalles Bibliográficos
Autores principales: Keihanfar, Mina, Mirjalili, Bi Bi Fatemeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8897970/
https://www.ncbi.nlm.nih.gov/pubmed/35246233
http://dx.doi.org/10.1186/s13065-022-00802-4
Descripción
Sumario:BACKGROUND: A new, green and environmentally friendly protocol has been developed for the synthesis of tetrahydrodipyrazolopyridine derivatives. The structures of these products were determined in terms of melting point, FTIR, NMR and Mass spectroscopy. RESULTS: The tetrahydrodipyrazolopyridine derivatives were synthesized in water through a catalyst-free pseudo-six-component reaction of hydrazine hydrate, ethyl acetoacetate, ammonium acetate and aldehyde at room temperature. CONCLUSIONS: This novel procedure has some advantages such as aqueous media, high yield and simple work-up. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13065-022-00802-4.

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