Redox regulation of age-associated defects in generation and maintenance of T cell self-tolerance and immunity to foreign antigens

Thymic atrophy reduces naive T cell production and contributes to increased susceptibility to viral infection with age. Expression of tissue-restricted antigen (TRA) genes also declines with age and has been thought to increase autoimmune disease susceptibility. We find that diminished expression of...

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Detalles Bibliográficos
Autores principales: Hester, Allison K., Semwal, Manpreet K., Cepeda, Sergio, Xiao, Yangming, Rueda, Meghan, Wimberly, Kymberly, Venables, Thomas, Dileepan, Thamotharampillai, Kraig, Ellen, Griffith, Ann V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898380/
https://www.ncbi.nlm.nih.gov/pubmed/35172147
http://dx.doi.org/10.1016/j.celrep.2022.110363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898380/
https://www.ncbi.nlm.nih.gov/pubmed/35172147
http://dx.doi.org/10.1016/j.celrep.2022.110363

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