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Energy deprivation-induced AMPK activation inhibits milk synthesis by targeting PrlR and PGC-1α

BACKGROUND: The mammary gland is responsible for milk production and secretion, which is critical for neonatal health during lactation. Lactation efficiency is largely affected by energy status with unclear mechanism. RESULTS: In the current study, we found that synthesis of milk fat and protein was...

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Detalles Bibliográficos
Autores principales: Wu, Zhihui, Li, Qihui, Yang, Siwang, Zheng, Tenghui, Shao, Jiayuan, Guan, Wutai, Chen, Fang, Zhang, Shihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898430/
https://www.ncbi.nlm.nih.gov/pubmed/35248054
http://dx.doi.org/10.1186/s12964-022-00830-6