Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological α-synuclein

α-synuclein (α-syn) aggregation and accumulation drive neurodegeneration in Parkinson’s disease (PD). The substantia nigra of patients with PD contains excess iron, yet the underlying mechanism accounting for this iron accumulation is unclear. Here, we show that misfolded α-syn activates microglia,...

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Detalles Bibliográficos
Autores principales: Sterling, Jacob K., Kam, Tae-In, Guttha, Samyuktha, Park, Hyejin, Baumann, Bailey, Mehrabani-Tabari, Amir A., Schultz, Hannah, Anderson, Brandon, Alnemri, Ahab, Chou, Shih-Ching, Troncoso, Juan C., Dawson, Valina L., Dawson, Ted M., Dunaief, Joshua L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898592/
https://www.ncbi.nlm.nih.gov/pubmed/35172141
http://dx.doi.org/10.1016/j.celrep.2022.110358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898592/
https://www.ncbi.nlm.nih.gov/pubmed/35172141
http://dx.doi.org/10.1016/j.celrep.2022.110358

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