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Interleukin-6 triggers toxic neuronal iron sequestration in response to pathological α-synuclein
α-synuclein (α-syn) aggregation and accumulation drive neurodegeneration in Parkinson’s disease (PD). The substantia nigra of patients with PD contains excess iron, yet the underlying mechanism accounting for this iron accumulation is unclear. Here, we show that misfolded α-syn activates microglia,...
Autores principales: | Sterling, Jacob K., Kam, Tae-In, Guttha, Samyuktha, Park, Hyejin, Baumann, Bailey, Mehrabani-Tabari, Amir A., Schultz, Hannah, Anderson, Brandon, Alnemri, Ahab, Chou, Shih-Ching, Troncoso, Juan C., Dawson, Valina L., Dawson, Ted M., Dunaief, Joshua L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898592/ https://www.ncbi.nlm.nih.gov/pubmed/35172141 http://dx.doi.org/10.1016/j.celrep.2022.110358 |
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