Naringin protects human nucleus pulposus cells against TNF-α-induced inflammation, oxidative stress, and loss of cellular homeostasis by enhancing autophagic flux via AMPK/SIRT1 activation

Activation of the proinflammatory-associated cytokine, tumor necrosis factor-α (TNF-α), in nucleus pulposus (NP) cells is essential for the pathogenesis of intervertebral disc degeneration (IDD). Restoring autophagic flux has been shown to effectively protect against IDD and is a potential target fo...

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Detalles Bibliográficos
Autores principales: Chen, Renchang, Gao, Shang, Guan, Huapeng, Zhang, Xin, Gao, Yuliang, Su, Youxiang, Song, Yun, Jiang, Yuehua, Li, Nianhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898769/
https://www.ncbi.nlm.nih.gov/pubmed/35265264
http://dx.doi.org/10.1155/2022/7655142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898769/
https://www.ncbi.nlm.nih.gov/pubmed/35265264
http://dx.doi.org/10.1155/2022/7655142

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