Cargando…

NPT1220-312, a TLR2/TLR9 Small Molecule Antagonist, Inhibits Pro-Inflammatory Signaling, Cytokine Release, and NLRP3 Inflammasome Activation

Toll-like receptors (TLRs) play a critical role in innate immune system responses to damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs). A growing body of evidence suggests that excessive TLR-mediated innate immune system activation can lead to neuronal d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Habas, Agata, Reddy Natala, Srinivasa, Bowden-Verhoek, Jon K., Stocking, Emily M., Price, Diana L., Wrasidlo, Wolfgang, Bonhaus, Douglas W., Gill, Martin B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8898874/ https://www.ncbi.nlm.nih.gov/pubmed/35265316 http://dx.doi.org/10.1155/2022/2337363

Ejemplares similares

The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson’s disease
por: Price, Diana L., et al.
Publicado: (2018)

Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4
por: McNeela, Edel A., et al.
Publicado: (2010)

Prognostic Value of NLRP3 Inflammasome and TLR4 Expression in Breast Cancer Patients
por: Saponaro, Concetta, et al.
Publicado: (2021)

TLR and NLRP3 inflammasome-dependent innate immune responses to tumor-derived autophagosomes (DRibbles)
por: Xing, Y, et al.
Publicado: (2016)

TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease
por: Yang, Junling, et al.
Publicado: (2020)

Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes
por: Ward, Grace A., et al.
Publicado: (2023)

Staphylococcus aureus increases Prostaglandin E(2) secretion in cow neutrophils by activating TLR2, TLR4, and NLRP3 inflammasome signaling pathways
por: Zhang, Kai, et al.
Publicado: (2023)

Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3
por: Kang, Seokwon, et al.
Publicado: (2015)

TLR4 Enhances Cerebral Ischemia/Reperfusion Injury via Regulating NLRP3 Inflammasome and Autophagy
por: Mao, Li, et al.
Publicado: (2023)

The TLR4/TRIF-Mediated Activation of NLRP3 Inflammasome Underlies Endotoxin-Induced Liver Injury in Mice
por: Tsutsui, Hiroko, et al.
Publicado: (2010)

Anti-dsDNA antibodies bind to TLR4 and activate NLRP3 inflammasome in lupus monocytes/macrophages
por: Zhang, Hui, et al.
Publicado: (2016)

TLR2-Melatonin Feedback Loop Regulates the Activation of NLRP3 Inflammasome in Murine Allergic Airway Inflammation
por: Wu, Hui-Mei, et al.
Publicado: (2020)

Sal B Alleviates Myocardial Ischemic Injury by Inhibiting TLR4 and the Priming Phase of NLRP3 Inflammasome
por: Hu, Yang, et al.
Publicado: (2019)

Fisetin Inhibits NLRP3 Inflammasome by Suppressing TLR4/MD2-Mediated Mitochondrial ROS Production
por: Molagoda, Ilandarage Menu Neelaka, et al.
Publicado: (2021)

CD38 Enhances TLR9 Expression and Activates NLRP3 Inflammasome after Porcine Parvovirus Infection
por: Zheng, Yi, et al.
Publicado: (2022)

Catalpol Alleviates Depression by Inhibiting NLRP3 Inflammasome via TLR4/MAPK/NF-Kb Pathway
por: Liang, Xuemei, et al.
Publicado: (2023)

TLR2 and the NLRP3 inflammasome mediate IL-1β production in Prevotella nigrescens-infected dendritic cells
por: Jang, Hye-Mi, et al.
Publicado: (2021)

TLR9 regulates NLRP3 inflammasome activation via the NF-kB signaling pathway in diabetic nephropathy
por: Shen, Jinfeng, et al.
Publicado: (2022)

Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation
por: Gurung, Prajwal, et al.
Publicado: (2015)

The NLRP3-Caspase 1 Inflammasome Negatively Regulates Autophagy via TLR4-TRIF in Prion Peptide-Infected Microglia
por: Lai, Mengyu, et al.
Publicado: (2018)

Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition
por: de Carvalho, Renan V. H., et al.
Publicado: (2019)

Inhibition of TLR4 Induces M2 Microglial Polarization and Provides Neuroprotection via the NLRP3 Inflammasome in Alzheimer’s Disease
por: Cui, Weigang, et al.
Publicado: (2020)

A Novel TLR4-Binding Domain of Peroxiredoxin From Entamoeba histolytica Triggers NLRP3 Inflammasome Activation in Macrophages
por: Li, Xia, et al.
Publicado: (2021)

Atorvastatin suppresses NLRP3 inflammasome activation in intracerebral hemorrhage via TLR4- and MyD88-dependent pathways
por: Chen, Duo, et al.
Publicado: (2022)

TLR priming licenses NAIP inflammasome activation by immunoevasive ligands
por: Grayczyk, James P., et al.
Publicado: (2023)

Investigation of TLR4 Antagonists for Prevention of Intestinal Inflammation
por: Tam, Janine S. Y., et al.
Publicado: (2022)

The Human-Associated Archaeon Methanosphaera stadtmanae Is Recognized through Its RNA and Induces TLR8-Dependent NLRP3 Inflammasome Activation
por: Vierbuchen, Tim, et al.
Publicado: (2017)

Knockdown of LRRK2 inhibits the progression of lung cancer by regulating TLR4/NF-κB pathways and NLRP3 inflammasome
por: Wu, Junfang, et al.
Publicado: (2023)

Synthetic glycolipid-based TLR4 antagonists negatively regulate TRIF-dependent TLR4 signalling in human macrophages
por: Palmer, Charys, et al.
Publicado: (2021)

Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells
por: Pothlichet, Julien, et al.
Publicado: (2013)

Baicalein ameliorates TNBS-induced colitis by suppressing TLR4/MyD88 signaling cascade and NLRP3 inflammasome activation in mice
por: Luo, Xiaoping, et al.
Publicado: (2017)

Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR
por: Leng, Bin, et al.
Publicado: (2019)

Publisher Correction: Leishmania RNA virus exacerbates Leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition
por: de Carvalho, Renan V. H., et al.
Publicado: (2020)

Palmitic acid stimulates NLRP3 inflammasome activation through TLR4-NF-κB signal pathway in hepatic stellate cells
por: Dong, Zhixia, et al.
Publicado: (2020)

Extracellular vesicles secreted by Giardia duodenalis regulate host cell innate immunity via TLR2 and NLRP3 inflammasome signaling pathways
por: Zhao, Panpan, et al.
Publicado: (2021)

Berberine ameliorates aGVHD by gut microbiota remodelling, TLR4 signalling suppression and colonic barrier repairment for NLRP3 inflammasome inhibition
por: Zhao, Yanna, et al.
Publicado: (2022)

Dietary Fatty Acid Regulation of the NLRP3 Inflammasome via the TLR4/NF-κB Signaling Pathway Affects Chondrocyte Pyroptosis
por: Jin, Xin, et al.
Publicado: (2022)

Caffeine Inhibits NLRP3 Inflammasome Activation by Downregulating TLR4/MAPK/NF-κB Signaling Pathway in an Experimental NASH Model
por: Vargas-Pozada, Eduardo E., et al.
Publicado: (2022)

MPL Adjuvant Contains Competitive Antagonists of Human TLR4
por: Wang, Yi-Qi, et al.
Publicado: (2020)

Recent Advances on Small-Molecule Antagonists Targeting TLR7
por: Zheng, Haoyang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_0cueoovpkm4ct0osd3rvb1ji4h