Detection of the ABCB11930_1931del TC Mutation in Two Suspected Ivermectin-Sensitive Cats and Their Relatives by a Novel TaqMan Allelic Discrimination Assay

The multidrug resistance gene MDR1 (syn. ABCB1) encodes for the multidrug efflux transporter P-glycoprotein (P-gp), which is highly expressed at the blood-brain barrier and protects the brain from potentially neurotoxic compounds, such as ivermectin. MDR1 mutation in dogs is known to be linked to dr...

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Detalles Bibliográficos
Autores principales: Nürnberger, Daniela, Wagner, Lisa, Müller, Simon F., Leiting, Silke, Leidolf, Regina, Alber, Jörg, Hamann, Melanie, Geyer, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Veterinary Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899013/
https://www.ncbi.nlm.nih.gov/pubmed/35265692
http://dx.doi.org/10.3389/fvets.2021.808392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899013/
https://www.ncbi.nlm.nih.gov/pubmed/35265692
http://dx.doi.org/10.3389/fvets.2021.808392

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