Sex‐related differential susceptibility to ponatinib cardiotoxicity and differential modulation of the Notch1 signalling pathway in a murine model

Ponatinib (PON), a tyrosine kinase inhibitor approved in chronic myeloid leukaemia, has proven cardiovascular toxicity. We assessed mechanisms of sex‐related PON‐induced cardiotoxicity and identified rescue strategies in a murine model. PON+scrambled siRNA‐treated male mice had a higher number of TU...

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Detalles Bibliográficos
Autores principales: Madonna, Rosalinda, Pieragostino, Damiana, Cufaro, Maria Concetta, Del Boccio, Piero, Pucci, Angela, Mattii, Letizia, Doria, Vanessa, Cadeddu Dessalvi, Christian, Zucchi, Riccardo, Mercuro, Giuseppe, De Caterina, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899159/
https://www.ncbi.nlm.nih.gov/pubmed/35122387
http://dx.doi.org/10.1111/jcmm.17008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899159/
https://www.ncbi.nlm.nih.gov/pubmed/35122387
http://dx.doi.org/10.1111/jcmm.17008

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