Comprehensive Analysis of Somatic Reversion Mutations in Homologous Recombination Repair (HRR) Genes in A Large Cohort of Chinese Pan-cancer Patients

Purpose: Mutations leading to homologous recombination deficiency (HRD) increase the tumor sensitivity to platinum-based chemotherapy and PARP inhibitors. However, reversion mutations often develop conferring acquired drug resistance. There is still a lack of comprehensive investigation on HRR rever...

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Detalles Bibliográficos
Autores principales: Zong, Hong, Zhang, Jian, Xu, Zhengyang, Pan, Jia-Ni, Wang, Rong, Han, Jinming, Jiang, Miao, Ren, Ruiping, Zang, Li, Wang, Haitao, Cao, Wen-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899361/
https://www.ncbi.nlm.nih.gov/pubmed/35281878
http://dx.doi.org/10.7150/jca.65650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899361/
https://www.ncbi.nlm.nih.gov/pubmed/35281878
http://dx.doi.org/10.7150/jca.65650

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