Structure-Activity Relationship Studies of 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen-2-yl)-1,3,5-triazin-2-amine (FPMINT) Analogues as Inhibitors of Human Equilibrative Nucleoside Transporters

Equilibrative nucleoside transporters (ENTs) play a vital role in nucleotide synthesis, regulation of adenosine function and chemotherapy. Current inhibitors of ENTs are mostly ENT1-selective. Our previous study has demonstrated that 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen...

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Detalles Bibliográficos
Autores principales: Li, Renkai, Mak, Winston Wing-Shum, Li, Jingjing, Zheng, Chengwen, Shiu, Polly Ho-Ting, Seto, Sai-Wang, Lee, Simon Ming-Yuen, Leung, George Pak-Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899516/
https://www.ncbi.nlm.nih.gov/pubmed/35264969
http://dx.doi.org/10.3389/fphar.2022.837555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899516/
https://www.ncbi.nlm.nih.gov/pubmed/35264969
http://dx.doi.org/10.3389/fphar.2022.837555

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