Cargando…

Structure-Activity Relationship Studies of 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen-2-yl)-1,3,5-triazin-2-amine (FPMINT) Analogues as Inhibitors of Human Equilibrative Nucleoside Transporters

Equilibrative nucleoside transporters (ENTs) play a vital role in nucleotide synthesis, regulation of adenosine function and chemotherapy. Current inhibitors of ENTs are mostly ENT1-selective. Our previous study has demonstrated that 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Renkai, Mak, Winston Wing-Shum, Li, Jingjing, Zheng, Chengwen, Shiu, Polly Ho-Ting, Seto, Sai-Wang, Lee, Simon Ming-Yuen, Leung, George Pak-Heng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899516/ https://www.ncbi.nlm.nih.gov/pubmed/35264969 http://dx.doi.org/10.3389/fphar.2022.837555

Ejemplares similares

1-[Bis(4-fluorophenyl)methyl]-4-[2-(naphthalen-2-yloxy)ethyl]piperazine
por: Zhong, Yan, et al.
Publicado: (2012)

4-Bromo-2-[(E)-(4-fluorophenyl)iminomethyl]phenol
por: Ardakani, Amir Adabi, et al.
Publicado: (2011)

4-Chloro-2-[(E)-(4-fluorophenyl)iminomethyl]phenol
por: Feng, Tian-Jun
Publicado: (2013)

1-[Bis(4-fluorophenyl)methyl]piperazine
por: Dayananda, A. S., et al.
Publicado: (2012)

2-Methoxy-4-[(4-methylpiperazin-1-yl)iminomethyl]phenol
por: Zhou, Li-Na, et al.
Publicado: (2010)

1-[Bis(4-fluorophenyl)methyl]-4-[2-(2-methylphenoxy)ethyl]piperazine
por: Dai, Zhao-Hui, et al.
Publicado: (2012)

(E)-2-[(4-Fluorophenyl)iminomethyl]-5-methoxyphenol
por: Albayrak, Çiğdem, et al.
Publicado: (2010)

N-(3-Chloro-4-fluorophenyl)-2-(naphthalen-1-yl)acetamide
por: Praveen, A. S., et al.
Publicado: (2011)

(2,7-Dimethoxynaphthalen-1-yl)(4-fluorophenyl)methanone
por: Watanabe, Shoji, et al.
Publicado: (2011)

1-{4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl}ethanone
por: Dayananda, A. S., et al.
Publicado: (2012)

(E)-3-(2-Ethoxyphenyl)-1-{4-[(2-fluorophenyl)(4-fluorophenyl)methyl]piperazin-1-yl}prop-2-en-1-one
por: Zhong, Yan, et al.
Publicado: (2012)

2-[(E)-(Naphthalen-2-yl)iminomethyl]phenol
por: Sharif, Hafiz Muhammad Adeel, et al.
Publicado: (2012)

2-Amino-4-(4-fluorophenyl)-6-(naphthalen-1-yl)pyridine-3-carbonitrile
por: Wang, Jian-Qiang, et al.
Publicado: (2010)

2-{2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)-4-phenylpyridazin-3(2H)-one
por: Aydın, Abdullah, et al.
Publicado: (2011)

2-[(E)-(Naphthalen-2-ylimino)methyl]-4-(trifluoromethoxy)phenol
por: Pekdemir, Merve, et al.
Publicado: (2012)

Dichlorido(2-{[2-(piperazin-4-ium-1-yl)ethyl]iminomethyl}phenolate)cadmium(II)
por: Saleh Salga, Muhammad, et al.
Publicado: (2010)

1,8-Bis(4-fluorophenyl)naphthalene
por: Feng, Jin-Wu, et al.
Publicado: (2011)

[2,7-Dibutoxy-8-(4-fluorobenzoyl)naphthalen-1-yl](4-fluorophenyl)methanone
por: Hijikata, Daichi, et al.
Publicado: (2012)

[2,7-Diethoxy-8-(4-fluorobenzoyl)naphthalen-1-yl](4-fluorophenyl)methanone
por: Mouri, Saki, et al.
Publicado: (2013)

Dibromido{2-[(4-fluorophenyl)iminomethyl]pyridine-κ(2) N,N′}zinc
por: Dehghanpour, Saeed, et al.
Publicado: (2012)

2,4,6-Tris(2,4-dimethylphenyl)-1,3,5-triazine
por: Huang, Jin-Sheng, et al.
Publicado: (2012)

Dichlorido(4-methoxy-2-{[2-(piperazin-4-ium-1-yl)ethyl]iminomethyl}phenolate)cadmium
por: Saleh Salga, Muhammad, et al.
Publicado: (2011)

(E)-2-[(3-Fluorophenyl)iminomethyl]-4-(trifluoromethoxy)phenol
por: Bingöl Alpaslan, Yelda, et al.
Publicado: (2010)

2-Amino-4-(3-fluorophenyl)-6-(naphthalen-1-yl)pyridine-3-carbonitrile
por: Xu, Jia-Ying, et al.
Publicado: (2010)

(E)-1-[(2-Fluorophenyl)iminomethyl]-2-naphthol–(Z)-1-[(2-fluorophenyl)aminomethylidene]naphthalen-2(1H)-one (0.57/0.43)
por: Alpaslan, Gökhan, et al.
Publicado: (2010)

(4-Fluorophenyl)[8-(4-fluorobenzoyl)-2,7-diphenoxynaphthalen-1-yl]methanone
por: Hijikata, Daichi, et al.
Publicado: (2012)

Crystal structure of tert-butyl 4-[4-(4-fluorophenyl)-2-methylbut-3-yn-2-yl]piperazine-1-carboxylate
por: Gumireddy, Ashwini, et al.
Publicado: (2021)

9-{4-[(E)-2-(4,6-Dimethyl-1,3,5-triazin-2-yl)ethenyl]phenyl}-9H-carbazole
por: Liu, Chang-Lin, et al.
Publicado: (2009)

2,4-Bis(morpholin-4-yl)-6-phenoxy-1,3,5-triazine
por: Vennila, Jasmine P., et al.
Publicado: (2011)

4-Methylsulfanyl-6-(4-pyridyl)-1,3,5-triazin-2-amine
por: Wu, Ya-Pan, et al.
Publicado: (2011)

6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diamine
por: Thanigaimani, Kaliyaperumal, et al.
Publicado: (2012)

2,2′-{[4,6-Bis(octylamino)-1,3,5-triazin-2-yl]azanediyl}diethanol
por: Sun, Hong-Hua, et al.
Publicado: (2012)

Methyl 2-(4,6-dichloro-1,3,5-triazin-2-ylamino)acetate
por: Vilela, Sérgio M. F., et al.
Publicado: (2009)

Advances in the Chemistry of 2,4,6‐Tri(thiophen‐2‐yl)‐1,3,5‐triazine
por: Rani Kumar, Neha, et al.
Publicado: (2023)

2-Chloro-4,6-bis(piperidin-1-yl)-1,3,5-triazine
por: Vennila, Jasmine P., et al.
Publicado: (2011)

1-{(E)-[4-Bromo-2-(trifluoromethoxy)phenyl]iminomethyl}naphthalen-2-ol
por: Kargılı, Hakan, et al.
Publicado: (2013)

(E)-1-{4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl}-3-(4-ethoxyphenyl)prop-2-en-1-one
por: Zhong, Yan, et al.
Publicado: (2011)

(E)-1-{4-[Bis(4-methoxyphenyl)methyl]piperazin-1-yl}-3-(4-fluorophenyl)prop-2-en-1-one
por: Teng, Yan-Bo, et al.
Publicado: (2011)

1-[Bis(4-fluorophenyl)methyl]-4-[(2Z)-3-phenylprop-2-en-1-yl]piperazine-1,4-diium dichloride hemihydrate
por: Shivaprakash, S., et al.
Publicado: (2014)

(E)-1-[(2-Chloro-4-nitrophenylimino)methyl]naphthalen-2-ol
por: Wang, Juangang, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_lhsvh45v7itt31gah26blg8hku