In vivo outer hair cell gene editing ameliorates progressive hearing loss in dominant-negative Kcnq4 murine model

Outer hair cell (OHC) degeneration is a major cause of progressive hearing loss and presbycusis. Despite the high prevalence of these disorders, targeted therapy is currently not available. Methods: We generated a mouse model harboring Kcnq4(W276S/+) to recapitulate DFNA2, a common genetic form of p...

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Detalles Bibliográficos
Autores principales: Noh, Byunghwa, Rim, John Hoon, Gopalappa, Ramu, Lin, Haiyue, Kim, Kyu Min, Kang, Min Jin, Gee, Heon Yung, Choi, Jae Young, Kim, Hyongbum Henry, Jung, Jinsei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899569/
https://www.ncbi.nlm.nih.gov/pubmed/35265220
http://dx.doi.org/10.7150/thno.67781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899569/
https://www.ncbi.nlm.nih.gov/pubmed/35265220
http://dx.doi.org/10.7150/thno.67781

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