An engineered bacterial therapeutic lowers urinary oxalate in preclinical models and in silico simulations of enteric hyperoxaluria

Enteric hyperoxaluria (EH) is a metabolic disease caused by excessive absorption of dietary oxalate leading to the formation of chronic kidney stones and kidney failure. There are no approved pharmaceutical treatments for EH. SYNB8802 is an engineered bacterial therapeutic designed to consume oxalat...

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Detalles Bibliográficos
Autores principales: Lubkowicz, David, Horvath, Nicholas G, James, Michael J, Cantarella, Pasquale, Renaud, Lauren, Bergeron, Christopher G, Shmueli, Ron B, Anderson, Cami, Gao, Jian‐Rong, Kurtz, Caroline B, Perreault, Mylene, Charbonneau, Mark R, Isabella, Vincent M, Hava, David L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899768/
https://www.ncbi.nlm.nih.gov/pubmed/35253995
http://dx.doi.org/10.15252/msb.202110539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899768/
https://www.ncbi.nlm.nih.gov/pubmed/35253995
http://dx.doi.org/10.15252/msb.202110539

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