Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours

The cells with compromised BRCA1 or BRCA2 (BRCA1/2) function accumulate stalled replication forks, which leads to replication‐associated DNA damage and genomic instability, a signature of BRCA1/2‐mutated tumours. Targeted therapies against BRCA1/2‐mutated tumours exploit this vulnerability by introd...

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Detalles Bibliográficos
Autores principales: Groelly, Florian J, Porru, Manuela, Zimmer, Jutta, Benainous, Hugo, De Visser, Yanti, Kosova, Anastasiya A, Di Vito, Serena, Serra, Violeta, Ryan, Anderson, Leonetti, Carlo, Bruna, Alejandra, Biroccio, Annamaria, Tarsounas, Madalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899905/
https://www.ncbi.nlm.nih.gov/pubmed/35107878
http://dx.doi.org/10.15252/emmm.202114501

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899905/
https://www.ncbi.nlm.nih.gov/pubmed/35107878
http://dx.doi.org/10.15252/emmm.202114501

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