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DNA Damage and Activation of cGAS/STING Pathway Induce Tumor Microenvironment Remodeling
DNA damage occurs throughout tumorigenesis and development. The immunogenicity of DNA makes it an immune stimulatory molecule that initiates strong inflammatory responses. The cGAS/STING pathway has been investigated as a critical receptor in both exogenous and endogenous DNA sensing to activate the...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900217/ https://www.ncbi.nlm.nih.gov/pubmed/35265630 http://dx.doi.org/10.3389/fcell.2021.828657 |