Tumor-B-cell interactions promote isotype switching to an immunosuppressive IgG4 antibody response through upregulation of IL-10 in triple negative breast cancers

BACKGROUND: Triple negative breast cancer (TNBC) is an aggressive breast cancer for which there is currently no targeted therapy. Tumor-infiltrating B-cells (TIB) have been observed in tumor tissues of TNBC patients, but their functional role is unclear. IgG4 is one of four antibody subclasses of Ig...

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Detalles Bibliográficos
Autores principales: Toney, Nicole J., Opdenaker, Lynn M., Cicek, Kader, Frerichs, Lisa, Kennington, Christopher Ryan, Oberly, Samuel, Archinal, Holly, Somasundaram, Rajasekharan, Sims-Mourtada, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900352/
https://www.ncbi.nlm.nih.gov/pubmed/35255925
http://dx.doi.org/10.1186/s12967-022-03319-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900352/
https://www.ncbi.nlm.nih.gov/pubmed/35255925
http://dx.doi.org/10.1186/s12967-022-03319-5

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