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Generation of immunodeficient pig with hereditary tyrosinemia type 1 and their preliminary application for humanized liver

BACKGROUND: Mice with humanized livers are important models to study drug toxicology testing, development of hepatitis virus treatments, and hepatocyte transplantation therapy. However, the huge difference between mouse and human in size and anatomy limited the application of humanized mice in inves...

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Detalles Bibliográficos
Autores principales: Ren, Jilong, Yu, Dawei, Wang, Jing, Xu, Kai, Xu, Yanan, Sun, Renren, An, Peipei, Li, Chongyang, Feng, Guihai, Zhang, Ying, Dai, Xiangpeng, Zhao, Hongye, Wang, Zhengzhu, Han, Zhiqiang, Zhu, Haibo, Ding, Yuchun, You, Xiaoyan, Liu, Xueqin, Wu, Meng, Luo, Lin, Li, Ziyi, Yang, Yong-Guang, Hu, Zheng, Wei, Hong-jiang, Ge, Liangpeng, Hai, Tang, Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900390/
https://www.ncbi.nlm.nih.gov/pubmed/35255981
http://dx.doi.org/10.1186/s13578-022-00760-3