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Regulation of paternal 5mC oxidation and H3K9me2 asymmetry by ERK1/2 in mouse zygotes

BACKGROUND: Extracellular-signal-regulated kinase (ERK) direct cell fate determination during the early development. The intricate interaction between the deposition of H3K9me2, de novo 5mC, and its oxides affects the remodeling of zygotic epigenetic modification. However, the role of fertilization-...

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Detalles Bibliográficos
Autores principales: Chen, Baobao, Deng, Mingtian, Pan, Meng-Hao, Sun, Shao-Chen, Liu, Honglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900417/
https://www.ncbi.nlm.nih.gov/pubmed/35255956
http://dx.doi.org/10.1186/s13578-022-00758-x