Long-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson’s disease mouse model

BACKGROUND: Growing evidence suggests an association between Parkinson’s disease (PD) and diabetes mellitus (DM). At the cellular level, long-term elevated levels of glucose have been shown to lead to nigrostriatal degeneration in PD models. However, the underlying mechanism is still unclear. Previo...

Descripción completa

Detalles Bibliográficos
Autores principales: Lv, Yi-Qing, Yuan, Lin, Sun, Yan, Dou, Hao-Wen, Su, Ji-Hui, Hou, Zhi-Pan, Li, Jia-Yi, Li, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900445/
https://www.ncbi.nlm.nih.gov/pubmed/35255986
http://dx.doi.org/10.1186/s40035-022-00288-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900445/
https://www.ncbi.nlm.nih.gov/pubmed/35255986
http://dx.doi.org/10.1186/s40035-022-00288-z

Ejemplares similares