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Long-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson’s disease mouse model

BACKGROUND: Growing evidence suggests an association between Parkinson’s disease (PD) and diabetes mellitus (DM). At the cellular level, long-term elevated levels of glucose have been shown to lead to nigrostriatal degeneration in PD models. However, the underlying mechanism is still unclear. Previo...

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Detalles Bibliográficos
Autores principales:	Lv, Yi-Qing, Yuan, Lin, Sun, Yan, Dou, Hao-Wen, Su, Ji-Hui, Hou, Zhi-Pan, Li, Jia-Yi, Li, Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900445/ https://www.ncbi.nlm.nih.gov/pubmed/35255986 http://dx.doi.org/10.1186/s40035-022-00288-z

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