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Pivotal role of a conserved histidine in Escherichia coli ribonuclease HI as proposed by X-ray crystallography

The ribonuclease (RNase) H family of enzymes catalyze the specific cleavage of RNA strands of RNA/DNA hybrid duplexes and play an important role in DNA replication and repair. Since the first report of the crystal structure of RNase HI, its catalytic mechanisms, which require metal ions, have been d...

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Detalles Bibliográficos
Autores principales: Liao, Zengwei, Oyama, Takuji, Kitagawa, Yumi, Katayanagi, Katsuo, Morikawa, Kosuke, Oda, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900815/
https://www.ncbi.nlm.nih.gov/pubmed/35234152
http://dx.doi.org/10.1107/S2059798322000870