A recurring packing contact in crystals of InlB pinpoints functional binding sites in the internalin domain and the B repeat

InlB, a bacterial agonist of the human receptor tyrosine kinase MET, consists of an N-terminal internalin domain, a central B repeat and three C-terminal GW domains. In all previous structures of full-length InlB or an InlB construct lacking the GW domains (InlB(392)), there was no interpretable ele...

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Detalles Bibliográficos
Autores principales: Geerds, Christina, Bleymüller, Willem M., Meyer, Timo, Widmann, Christiane, Niemann, Hartmut H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2022
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900821/
https://www.ncbi.nlm.nih.gov/pubmed/35234145
http://dx.doi.org/10.1107/S2059798322000432

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900821/
https://www.ncbi.nlm.nih.gov/pubmed/35234145
http://dx.doi.org/10.1107/S2059798322000432

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