Interactions between 2′-fluoro-(carbamoyl­pyridinyl)deschloroepibatidine analogues and acetylcholine-binding protein inform on potent antagonist activity against nicotinic receptors

Low-nanomolar binding constants were recorded for a series of six 2′-fluoro-(carbamoylpyridinyl)deschloroepibatidine analogues with acetylcholine-binding protein (AChBP). The crystal structures of three complexes with AChBP reveal details of molecular recognition in the orthosteric binding site and...

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Detalles Bibliográficos
Autores principales: Bueno, Renata V., Davis, Samuel, Dawson, Alice, Ondachi, Pauline W., Carroll, F. Ivy, Hunter, William N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2022
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900824/
https://www.ncbi.nlm.nih.gov/pubmed/35234149
http://dx.doi.org/10.1107/S2059798322000754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900824/
https://www.ncbi.nlm.nih.gov/pubmed/35234149
http://dx.doi.org/10.1107/S2059798322000754

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