Cargando…

Interactions between 2′-fluoro-(carbamoylpyridinyl)deschloroepibatidine analogues and acetylcholine-binding protein inform on potent antagonist activity against nicotinic receptors

Low-nanomolar binding constants were recorded for a series of six 2′-fluoro-(carbamoylpyridinyl)deschloroepibatidine analogues with acetylcholine-binding protein (AChBP). The crystal structures of three complexes with AChBP reveal details of molecular recognition in the orthosteric binding site and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bueno, Renata V., Davis, Samuel, Dawson, Alice, Ondachi, Pauline W., Carroll, F. Ivy, Hunter, William N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2022
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8900824/ https://www.ncbi.nlm.nih.gov/pubmed/35234149 http://dx.doi.org/10.1107/S2059798322000754

Ejemplares similares

Synthesis, Nicotinic Acetylcholine Receptor Binding, and Antinociceptive Properties of 2′-Fluoro-3′-(substituted pyridinyl)-7-deschloroepibatidine Analogues
por: Ondachi, Pauline W., et al.
Publicado: (2014)

Synthesis and Antagonist Activity of Methyllycaconitine Analogues on Human α7 Nicotinic Acetylcholine Receptors
por: Qasem, Ashraf M. A., et al.
Publicado: (2023)

(−)-Adaline from the Adalia Genus of Ladybirds Is a Potent Antagonist of Insect and Specific Mammalian Nicotinic Acetylcholine Receptors
por: Richards, David P., et al.
Publicado: (2022)

Delineating the activity of the potent nicotinic acetylcholine receptor agonists (+)-anatoxin-a and (−)-hosieine-A
por: Parker, Holly P., et al.
Publicado: (2022)

Methylpiperidinium Iodides as Novel Antagonists for α7 Nicotinic Acetylcholine Receptors
por: López, Jhon J., et al.
Publicado: (2018)

Action of Carvacrol on Parascaris sp. and Antagonistic Effect on Nicotinic Acetylcholine Receptors
por: Trailovic, Sasa M., et al.
Publicado: (2021)

2-Carbamoyl-3,4,5,6-tetrafluorobenzoic acid
por: Lu, Tao, et al.
Publicado: (2012)

Ribbon α-Conotoxin KTM Exhibits Potent Inhibition of Nicotinic Acetylcholine Receptors
por: Marquart, Leanna A., et al.
Publicado: (2019)

Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine
por: Schapira, Matthieu, et al.
Publicado: (2002)

Discovery of a Potent and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist from an α-Conotoxin Synthetic Combinatorial Library
por: Chang, Yi-Pin, et al.
Publicado: (2014)

Unexpected loss of sensitivity to the nicotinic acetylcholine receptor antagonist activity of mecamylamine and dihydro‐β‐erythroidine in nicotine‐tolerant mice
por: de Moura, Fernando B., et al.
Publicado: (2020)

Synthesis of tetrasubstituted pyrazoles containing pyridinyl substituents
por: Jansa, Josef, et al.
Publicado: (2017)

Synthesis and biological evaluation of alpha-bromoacryloylamido indolyl pyridinyl propenones as potent apoptotic inducers in human leukaemia cells
por: Romagnoli, Romeo, et al.
Publicado: (2018)

Nicotinic acetylcholine receptors and cancer
por: DANG, NINGNING, et al.
Publicado: (2016)

PS106. Nicotinic acetylcholine receptor antagonists for treatment-resistant depression: A meta-analysis.
por: Wang, Hee Ryung, et al.
Publicado: (2016)

The potent and selective α4β2*/α6*-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-like behavior in animal models and a favorable ADME-tox profile
por: Yu, Li-Fang, et al.
Publicado: (2014)

Photochemical Organocatalytic Functionalization of Pyridines via Pyridinyl Radicals
por: Le Saux, Emilien, et al.
Publicado: (2022)

The missing crystal structure in the series of N,N′,N′′-tris(pyridinyl)benzene-1,3,5-tricarboxamides: the 2-pyridinyl derivative
por: Senior, Levi, et al.
Publicado: (2020)

2-{5-[N-(2-Pyridyl)carbamoyl]pentanamido}pyridinium hexafluorophosphate
por: Cheng, Pei-Chi, et al.
Publicado: (2009)

Monepantel is a non-competitive antagonist of nicotinic acetylcholine receptors from Ascaris suum and Oesophagostomum dentatum
por: Abongwa, Melanie, et al.
Publicado: (2017)

UFR2709, a Nicotinic Acetylcholine Receptor Antagonist, Decreases Ethanol Intake in Alcohol-Preferring Rats
por: Quiroz, Gabriel, et al.
Publicado: (2019)

The Oncogenic Functions of Nicotinic Acetylcholine Receptors
por: Zhao, Yue
Publicado: (2016)

Nicotinic acetylcholine receptors modulate osteoclastogenesis
por: Mandl, Peter, et al.
Publicado: (2016)

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors
por: Zoli, Michele, et al.
Publicado: (2018)

Evolution of vertebrate nicotinic acetylcholine receptors
por: Pedersen, Julia E., et al.
Publicado: (2019)

Nicotinic Acetylcholine Receptors in the Respiratory Tract
por: Hollenhorst, Monika I., et al.
Publicado: (2021)

Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a carbamoyl linker
por: Kokosza, Kamil, et al.
Publicado: (2013)

Indolyl-Pyridinyl-Propenone-Induced Methuosis through the Inhibition of PIKFYVE
por: Cho, Hyelim, et al.
Publicado: (2018)

Pyrazinyl and pyridinyl bis-azomethines formation: an experimental and computational study
por: Coufal, Radek, et al.
Publicado: (2023)

The Dinoflagellate Toxin 20-Methyl Spirolide-G Potently Blocks Skeletal Muscle and Neuronal Nicotinic Acetylcholine Receptors
por: Couesnon, Aurélie, et al.
Publicado: (2016)

Agonist and antagonist effects of tobacco-related nitrosamines on human α4β2 nicotinic acetylcholine receptors
por: Brusco, Simone, et al.
Publicado: (2015)

Inflammation Regulation via an Agonist and Antagonists of α7 Nicotinic Acetylcholine Receptors in RAW264.7 Macrophages
por: Tan, Yao, et al.
Publicado: (2022)

Molecular Recognition of the Neurotransmitter Acetylcholine by an Acetylcholine Binding Protein Reveals Determinants of Binding to Nicotinic Acetylcholine Receptors
por: Olsen, Jeppe A., et al.
Publicado: (2014)

Nicotinic Acetylcholine Receptor (nAChR) Dependent Chorda Tympani Taste Nerve Responses to Nicotine, Ethanol and Acetylcholine
por: Ren, Zuo Jun, et al.
Publicado: (2015)

Pathogenesis of Abdominal Aortic Aneurysms: Role of Nicotine and Nicotinic Acetylcholine Receptors
por: Li, Zong-Zhuang, et al.
Publicado: (2012)

Acetylcholine receptors in the retinas of the α7 nicotinic acetylcholine receptor knockout mouse
por: Smith, Marci L., et al.
Publicado: (2014)

Synthesis and Application of the Transition Metal Complexes of α-Pyridinyl Alcohols, α-Bipyridinyl Alcohols, α,α’-Pyridinyl Diols and α,α’-Bipyridinyl Diols in Homogeneous Catalysis
por: Tole, Tegene, et al.
Publicado: (2018)

The submembrane machinery for nicotinic acetylcholine receptor clustering
Publicado: (1991)

Mechanics of Channel Gating of the Nicotinic Acetylcholine Receptor
por: Liu, Xinli, et al.
Publicado: (2008)

Determinants Responsible for Assembly of the Nicotinic Acetylcholine Receptor
por: Keller, Steven H., et al.
Publicado: (1999)

Cannot write session to /tmp/vufind_sessions/sess_k9p6crs5996b4u0mh3nrtrg368