Rho kinase inhibition ameliorates vascular remodeling and blood pressure elevations in a rat model of apatinib-induced hypertension

Hypertension is one of the major adverse effects of tyrosine kinase inhibitors (TKIs) targeting vascular endothelial growth factors. However, the mechanism underlying TKIs-induced hypertension remains unclear. Here, we explored the role of the RhoA/Rho kinase (ROCK) signaling pathway in elevation of...

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Detalles Bibliográficos
Autores principales: Li, Caie, Ma, Liping, Wang, Qiongying, Shao, Xuejiao, Guo, Lu, Chen, Jianshu, Wang, Wenjuan, Yu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901036/
https://www.ncbi.nlm.nih.gov/pubmed/34862331
http://dx.doi.org/10.1097/HJH.0000000000003060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901036/
https://www.ncbi.nlm.nih.gov/pubmed/34862331
http://dx.doi.org/10.1097/HJH.0000000000003060

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