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Rho kinase inhibition ameliorates vascular remodeling and blood pressure elevations in a rat model of apatinib-induced hypertension

Hypertension is one of the major adverse effects of tyrosine kinase inhibitors (TKIs) targeting vascular endothelial growth factors. However, the mechanism underlying TKIs-induced hypertension remains unclear. Here, we explored the role of the RhoA/Rho kinase (ROCK) signaling pathway in elevation of...

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Detalles Bibliográficos
Autores principales:	Li, Caie, Ma, Liping, Wang, Qiongying, Shao, Xuejiao, Guo, Lu, Chen, Jianshu, Wang, Wenjuan, Yu, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901036/ https://www.ncbi.nlm.nih.gov/pubmed/34862331 http://dx.doi.org/10.1097/HJH.0000000000003060

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