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Computational maturation of a single-domain antibody against Aβ42 aggregation

The expansion of structural databases and the increase in computing power are enabling approaches for antibody discovery based on computational design. It has already been shown that it is possible to use this approach to generate antibodies for specific epitopes on challenging targets. Here we desc...

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Detalles Bibliográficos
Autores principales: Lin, Jiacheng, Figazzolo, Chiara, Metrick, Michael A., Sormanni, Pietro, Vendruscolo, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901120/
https://www.ncbi.nlm.nih.gov/pubmed/35475123
http://dx.doi.org/10.1039/d1sc03898b