Cargando…
Computational maturation of a single-domain antibody against Aβ42 aggregation
The expansion of structural databases and the increase in computing power are enabling approaches for antibody discovery based on computational design. It has already been shown that it is possible to use this approach to generate antibodies for specific epitopes on challenging targets. Here we desc...
Autores principales: | Lin, Jiacheng, Figazzolo, Chiara, Metrick, Michael A., Sormanni, Pietro, Vendruscolo, Michele |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901120/ https://www.ncbi.nlm.nih.gov/pubmed/35475123 http://dx.doi.org/10.1039/d1sc03898b |
Ejemplares similares
-
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method
por: Aprile, Francesco A., et al.
Publicado: (2017) -
Rationally Designed Bicyclic Peptides Prevent the Conversion of Aβ42 Assemblies Into Fibrillar Structures
por: Ikenoue, Tatsuya, et al.
Publicado: (2021) -
Conformational Entropy as a Potential Liability of Computationally Designed Antibodies
por: Löhr, Thomas, et al.
Publicado: (2022) -
Systematic Activity Maturation of a Single-Domain Antibody with Non-canonical Amino Acids through Chemical Mutagenesis
por: Lindstedt, Philip R., et al.
Publicado: (2021) -
A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells
por: Bongiovanni, Marie Nicole, et al.
Publicado: (2018)