The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation

BAX and BAK are key apoptosis regulators that mediate the decisive step of mitochondrial outer membrane permeabilization. However, the mechanism by which they assemble the apoptotic pore remains obscure. Here, we report that BAX and BAK present distinct oligomerization properties, with BAK organizin...

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Detalles Bibliográficos
Autores principales: Cosentino, Katia, Hertlein, Vanessa, Jenner, Andreas, Dellmann, Timo, Gojkovic, Milos, Peña-Blanco, Aida, Dadsena, Shashank, Wajngarten, Noel, Danial, John S.H., Thevathasan, Jervis Vermal, Mund, Markus, Ries, Jonas, Garcia-Saez, Ana J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901441/
https://www.ncbi.nlm.nih.gov/pubmed/35120587
http://dx.doi.org/10.1016/j.molcel.2022.01.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901441/
https://www.ncbi.nlm.nih.gov/pubmed/35120587
http://dx.doi.org/10.1016/j.molcel.2022.01.008

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