Targeting Mcl-1 by AMG-176 During Ibrutinib and Venetoclax Therapy in Chronic Lymphocytic Leukemia

B-cell receptor (BCR) signaling pathway and Bcl-2 family prosurvival proteins, specifically Bcl-2 and Mcl-1, are functional in the pathobiology of chronic lymphocytic leukemia (CLL). A pivotal and apical molecule in the BCR pathway is Bruton’s tyrosine kinase (BTK). Together, BTK, Bcl-2, and Mcl-1 p...

Descripción completa

Detalles Bibliográficos
Autores principales: Yi, Xue, Jain, Nitin, Iles, LaKesla R., Ayres, Mary L., Wierda, William G., Gandhi, Varsha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901605/
https://www.ncbi.nlm.nih.gov/pubmed/35273915
http://dx.doi.org/10.3389/fonc.2022.833714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901605/
https://www.ncbi.nlm.nih.gov/pubmed/35273915
http://dx.doi.org/10.3389/fonc.2022.833714

Ejemplares similares