LncRNA MEG3 up-regulates SIRT6 by ubiquitinating EZH2 and alleviates nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is a global health threat. Here, we presented the significant role of a novel signaling axis comprising long non-coding RNA maternally expressed gene 3 (MEG3), enhancer of zeste homolog 2 (EZH2), and sirtuin 6 (SIRT6) in controlling lipid accumulation, inflam...

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Detalles Bibliográficos
Autores principales: Zou, Dongmei, Liu, Liang, Zeng, Yinzhen, Wang, Huanhuan, Dai, Dongling, Xu, Mingguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901640/
https://www.ncbi.nlm.nih.gov/pubmed/35256601
http://dx.doi.org/10.1038/s41420-022-00889-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901640/
https://www.ncbi.nlm.nih.gov/pubmed/35256601
http://dx.doi.org/10.1038/s41420-022-00889-7

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