mTORC1 induces plasma membrane depolarization and promotes preosteoblast senescence by regulating the sodium channel Scn1a

Senescence impairs preosteoblast expansion and differentiation into functional osteoblasts, blunts their responses to bone formation-stimulating factors and stimulates their secretion of osteoclast-activating factors. Due to these adverse effects, preosteoblast senescence is a crucial target for the...

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Detalles Bibliográficos
Autores principales: Chen, Ajuan, Jin, Jian, Cheng, Shasha, Liu, Zezheng, Yang, Cheng, Chen, Qingjing, Liang, Wenquan, Li, Kai, Kang, Dawei, Ouyang, Zhicong, Yao, Chenfeng, Bai, Xiaochun, Li, Qingchu, Jin, Dadi, Huang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901653/
https://www.ncbi.nlm.nih.gov/pubmed/35256591
http://dx.doi.org/10.1038/s41413-022-00204-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901653/
https://www.ncbi.nlm.nih.gov/pubmed/35256591
http://dx.doi.org/10.1038/s41413-022-00204-1

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