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A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration

Articular cartilage repair and regeneration is an unmet clinical need because of the poor self-regeneration capacity of the tissue. In this study, we found that the expression of prostaglandin E receptor 4 (PTGER4 or EP4) was largely increased in the injured articular cartilage in both humans and mi...

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Detalles Bibliográficos
Autores principales: Jin, Yunyun, Liu, Qianqian, Chen, Peng, Zhao, Siyuan, Jiang, Wenhao, Wang, Fanhua, Li, Peng, Zhang, Yuanjin, Lu, Weiqiang, Zhong, Tao P., Ma, Xinran, Wang, Xin, Gartland, Alison, Wang, Ning, Shah, Karan Mehul, Zhang, Hankun, Cao, Xu, Yang, Lei, Liu, Mingyao, Luo, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901748/
https://www.ncbi.nlm.nih.gov/pubmed/35256606
http://dx.doi.org/10.1038/s41421-022-00382-6