Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer

Deregulation of the BCL-2 family interaction network ensures cancer resistance to apoptosis and is a major challenge to current treatments. Cancer cells commonly evade apoptosis through upregulation of the BCL-2 anti-apoptotic proteins; however, more resistant cancers also downregulate or inactivate...

Descripción completa

Detalles Bibliográficos
Autores principales: Lopez, Andrea, Reyna, Denis E., Gitego, Nadege, Kopp, Felix, Zhou, Hua, Miranda-Roman, Miguel A., Nordstrøm, Lars Ulrik, Narayanagari, Swathi-Rao, Chi, Ping, Vilar, Eduardo, Tsirigos, Aristotelis, Gavathiotis, Evripidis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901805/
https://www.ncbi.nlm.nih.gov/pubmed/35256598
http://dx.doi.org/10.1038/s41467-022-28741-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901805/
https://www.ncbi.nlm.nih.gov/pubmed/35256598
http://dx.doi.org/10.1038/s41467-022-28741-7

Ejemplares similares