Inhibition of USP28 overcomes Cisplatin-resistance of squamous tumors by suppression of the Fanconi anemia pathway

Squamous cell carcinomas (SCC) frequently have an exceptionally high mutational burden. As consequence, they rapidly develop resistance to platinum-based chemotherapy and overall survival is limited. Novel therapeutic strategies are therefore urgently required. SCC express ∆Np63, which regulates the...

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Detalles Bibliográficos
Autores principales: Prieto-Garcia, Cristian, Hartmann, Oliver, Reissland, Michaela, Fischer, Thomas, Maier, Carina R., Rosenfeldt, Mathias, Schülein-Völk, Christina, Klann, Kevin, Kalb, Reinhard, Dikic, Ivan, Münch, Christian, Diefenbacher, Markus E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901929/
https://www.ncbi.nlm.nih.gov/pubmed/34611298
http://dx.doi.org/10.1038/s41418-021-00875-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901929/
https://www.ncbi.nlm.nih.gov/pubmed/34611298
http://dx.doi.org/10.1038/s41418-021-00875-z

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